[123I]β‐CIT single‐photon emission tomography in DOPA‐responsive dystonia
Identifieur interne : 005214 ( Main/Exploration ); précédent : 005213; suivant : 005215[123I]β‐CIT single‐photon emission tomography in DOPA‐responsive dystonia
Auteurs : Naumann [Allemagne] ; Walter Pirker [Allemagne] ; Karlheinz Reiners [Allemagne] ; Klaus Lange [Allemagne] ; Georg Becker [Allemagne] ; Thomas Brücke [Allemagne]Source :
- Movement Disorders [ 0885-3185 ] ; 1997-05.
English descriptors
- KwdEn :
- Adult, Aged, Binding Sites, Cerebellum (metabolism), Cerebellum (radionuclide imaging), Corpus Striatum (metabolism), Corpus Striatum (radionuclide imaging), DOPA‐responsive dystonia, Diagnosis, Differential, Dopamine (metabolism), Dopamine transporter, Dystonia (drug therapy), Dystonia (radionuclide imaging), FD PET, Female, Humans, Levodopa (therapeutic use), Middle Aged, Radioactive Tracers, SPECT, Tomography, Emission-Computed, Single-Photon.
- MESH :
- chemical , metabolism : Dopamine.
- drug therapy : Dystonia.
- metabolism : Cerebellum, Corpus Striatum.
- radionuclide imaging : Cerebellum, Corpus Striatum, Dystonia.
- chemical , therapeutic use : Levodopa.
- Adult, Aged, Binding Sites, Diagnosis, Differential, Female, Humans, Middle Aged, Radioactive Tracers, Tomography, Emission-Computed, Single-Photon.
Abstract
The radiotracer [123I]β‐CIT is a sensitive marker of dopamine uptake sites that can be used to visualize dopaminergic nerve endings in vivo in the human brain. We report on [123I]β‐CIT single‐photon emission computed tomography (SPECT) findings in a patient with DOPA‐responsive dystonia (DRD). [123I]β‐CIT SPECT showed a striatal radiotracer uptake in the upper range of normal, indicating intact dopamine transporters and structural integrity of nigrostriatal neurons. This differentiates DRD from clinically similar cases with juvenile‐onset parkinsonism with dystonia that have a considerably poorer prognosis. [123I]β‐CIT SPECT may provide a method equally as useful as fluorodopa positron emission tomography in DRD.
Url:
DOI: 10.1002/mds.870120330
Affiliations:
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Freiburg</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="1997-05">1997-05</date><biblScope unit="vol">12</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="448">448</biblScope><biblScope unit="page" to="451">451</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">693EE99B2B66EC8D7FEC60F0C5F59AE7C6D1D65C</idno><idno type="DOI">10.1002/mds.870120330</idno><idno type="ArticleID">MDS870120330</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Binding Sites</term><term>Cerebellum (metabolism)</term><term>Cerebellum (radionuclide imaging)</term><term>Corpus Striatum (metabolism)</term><term>Corpus Striatum (radionuclide imaging)</term><term>DOPA‐responsive dystonia</term><term>Diagnosis, Differential</term><term>Dopamine (metabolism)</term><term>Dopamine transporter</term><term>Dystonia (drug therapy)</term><term>Dystonia (radionuclide imaging)</term><term>FD PET</term><term>Female</term><term>Humans</term><term>Levodopa (therapeutic use)</term><term>Middle Aged</term><term>Radioactive Tracers</term><term>SPECT</term><term>Tomography, Emission-Computed, Single-Photon</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Dopamine</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Dystonia</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Cerebellum</term><term>Corpus Striatum</term></keywords><keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Cerebellum</term><term>Corpus Striatum</term><term>Dystonia</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Levodopa</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Binding Sites</term><term>Diagnosis, Differential</term><term>Female</term><term>Humans</term><term>Middle Aged</term><term>Radioactive Tracers</term><term>Tomography, Emission-Computed, Single-Photon</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The radiotracer [123I]β‐CIT is a sensitive marker of dopamine uptake sites that can be used to visualize dopaminergic nerve endings in vivo in the human brain. We report on [123I]β‐CIT single‐photon emission computed tomography (SPECT) findings in a patient with DOPA‐responsive dystonia (DRD). [123I]β‐CIT SPECT showed a striatal radiotracer uptake in the upper range of normal, indicating intact dopamine transporters and structural integrity of nigrostriatal neurons. This differentiates DRD from clinically similar cases with juvenile‐onset parkinsonism with dystonia that have a considerably poorer prognosis. [123I]β‐CIT SPECT may provide a method equally as useful as fluorodopa positron emission tomography in DRD.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country></list><tree><country name="Allemagne"><noRegion><name sortKey="Naumann" sort="Naumann" uniqKey="Naumann" last="Naumann">Naumann</name></noRegion><name sortKey="Becker, Georg" sort="Becker, Georg" uniqKey="Becker G" first="Georg" last="Becker">Georg Becker</name><name sortKey="Brucke, Thomas" sort="Brucke, Thomas" uniqKey="Brucke T" first="Thomas" last="Brücke">Thomas Brücke</name><name sortKey="Lange, Klaus" sort="Lange, Klaus" uniqKey="Lange K" first="Klaus" last="Lange">Klaus Lange</name><name sortKey="Pirker, Walter" sort="Pirker, Walter" uniqKey="Pirker W" first="Walter" last="Pirker">Walter Pirker</name><name sortKey="Reiners, Karlheinz" sort="Reiners, Karlheinz" uniqKey="Reiners K" first="Karlheinz" last="Reiners">Karlheinz Reiners</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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